Garcia de Orta was born in Castelo de Vide, probably in 1501, the son of Fernão (Isaac) da Orta, a merchant, and Leonor Gomes. He had three sisters, Violante, Catarina and Isabel. Their parents were Spanish Jews from Valencia de Alcántara who had taken refuge, as many others did, in Portugal at the time of the great expulsion of the Spanish Jews by the Reyes Catolicos Ferdinand and Isabella of Spain in 1492. Forcibly converted to Christianity in 1497, they were pejoratively classed as Cristãos Novos (New Christians) and marranos ("swine"). Some of these refugees maintained their Jewish faith secretly. A friendly neighbor at Castelo de Vide was the nobleman Dom Fernão de Sousa, Lord of Labruja, who may have influenced the idea for Garcia's father to send him to University. Dom Fernão's son Martim Afonso de Sousa would become a key figure in later life.Garcia studied medicine, arts and philosophy at the Universities of Alcalá de Henares and Salamanca in Spain. He graduated and returned to Portugal in 1525, two years after his father's death. He practiced medicine first in his hometown and from 1526 onwards in Lisbon, where he gained a lectureship at the university in 1532. He also became a royal physician to John III of Portugal.Perhaps fearing the increasing power of the Portuguese Inquisition, and fortunately evading the ban on emigration of New Christians, he sailed for Portuguese India leaving the Tagus in March 1534 as Chief Physician aboard the fleet of Martim Afonso de Sousa, later to be named Governor. He reached Goa in September. He travelled with Sousa on various campaigns, then, in 1538, settled at Goa, where he soon had a prominent medical practice. He was a physician to Burhan Nizam Shah I of the Nizam Shahi dynasty of Ahmadnagar, and concurrently to several successive Portuguese Viceroys and governors of Goa. While Garcia de Orta was a physician of the Sultan and teacher of Portuguese of his son, the Prince, he met and dined several times with the high ranking cavalry general of the Sultan, Firangi Khan. Garcia de Orta reports that the cavalry commander violated sometimes religious directives, eating pork and drinking wine in these private dinners. Firangi Khan had converted to Islam for apparently material reasons and had a very important role in the court of the Sultanate, but subsidized charities to Misericórdias in the relationship he had with the Portuguese empire (despite serving an intermittent enemy Muslim state) and, according to Orta, "urged other Christians to never abdicate their principles." He even projected return to his home city in his country (already secretly pardoned by the viceroy Afonso de Noronha). Firangi Khan was not his title (and name, which literally means "foreigner Khan") of origin. His name was Sancho Pires, a formerly gunner (bombardeiro), Portuguese, and natural of Matosinhos. He died in battle in India [https://en.wikipedia.org/wiki/Garcia_de_Orta](https://en.wikipedia.org/wiki/Garcia_de_Orta)